2355. Clinafloxacin

Nomenclature

CAS number: 105956-97-6
7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid.
C17H17ClFN3O3; mol wt 365.79.
C 55.82%, H 4.68%, Cl 9.69%, F 5.19%, N 11.49%, O 13.12%.

Description and references

Fluorinated quinolone antibacterial. Prepn: S. Suzue et al., EP 195316 (1986 to Kyorin). Antibacterial spectrum: M. S. Barrett et al., Diagn. Microbiol. Infect. Dis. 14, 389 (1991); S. M. H. Qadri et al., Chemotherapy (Basel) 38, 92 (1992).

Chemical structure

Properties

Milk-white powder from chloroform-methanol-conc. aq. ammonia, mp 253-258° (dec).

Derivative

Hydrochloride.

Nomenclature

CAS number: 105956-99-8
AM-1091; CI-960; PD-127391.
C17H17ClFN3O3.HCl; mol wt 402.25.
C 50.76%, H 4.51%, Cl 17.63%, F 4.72%, N 10.45%, O 11.93%.

Properties

Light yellow prisms from methanol, mp 263-265° (dec).

Therapeutic Category

Antibacterial.

Keywords

Antibacterial (Synthetic); Quinolones and Analogs