2360. Clobenfurol

Nomenclature

CAS number: 3611-72-1
α-(4-Chlorophenyl)-2-benzofuranmethanol; 2-benzofuryl-p-chlorophenylcarbinol; Menacor (Menarini).
C15H11ClO2; mol wt 258.70.
C 69.64%, H 4.29%, Cl 13.70%, O 12.37%.

Description and references

Prepn: BE 644176; Ghelardoni, Russo, GB 1160925 (1964, 1969 both to Menarini), C.A. 63, 8319h (1965); 71, 124212f (1969); Ghelardoni, Russo, Boll. Chim. Farm. 109, 48 (1970). Pharmacology of the hemisuccinate deriv: Pisanti, Volterra, Farmaco Ed. Sci. 26, 312 (1971).

Chemical structure

Properties

White, odorless powder, mp 48-49°.

Derivative

Hemisuccinate.
C19H15ClO5; mol wt 358.77.
C 63.61%, H 4.21%, Cl 9.88%, O 22.30%.

Properties

mp 95-97° from petr ether. LD50 in mice, rats (mg/kg): 321, 300 i.p. (Pisanti, Volterra).

Therapeutic Category

Vasodilator (coronary).

Keywords

Vasodilator (Coronary)