2364. Clobetasone

Nomenclature

CAS number: 54063-32-0
(16β)-21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione; 21-chloro-11-dehydrobetamethasone.
C22H26ClFO4; mol wt 408.89.
C 64.62%, H 6.41%, Cl 8.67%, F 4.65%, O 15.65%.

Description and references

Prepn: Elks et al., DE 1902340; eidem, US 3721687 (1969, l973, both to Glaxo). Activity: Munro, Wilson, Br. Med. J. 3, 626 (1975). Radioimmunoassay: W. A. Webb, R. V. Brooks, Acta Endocrinol. Suppl. 212, 203 (1977). Toxicology: J. Tamura et al., J. Toxicol. Sci. 5, 45, 177 (1980). Comparative clinical studies: A. Lassus, Curr. Med. Res. Opin. 6, 165 (1979); T. Fredriksson, K. Nordin, ibid. 322. Clinical evaluation of ophthalmic form: D. Lloyd-Jones et al., Br. J. Ophthalmol. 65, 641 (1981); L. A. Eilon, S. R. Walker, ibid. 644; K. R. Wilhelmus et al., ibid. 699.

Chemical structure

Derivative

17-Butyrate.

Nomenclature

CAS number: 25122-57-0
GR-2/1214; Emovate (GSK); Eumovate (GSK).
C26H32ClFO5; mol wt 478.98.
C 65.20%, H 6.73%, Cl 7.40%, F 3.97%, O 16.70%.

Properties

Crystals from methanol, mp 90-100°.

Therapeutic Category

Glucocorticoid; anti-inflammatory.

Keywords

Glucocorticoid