2371. Clodronic Acid

Nomenclature

CAS number: 10596-23-3
(Dichloromethylene)bisphosphonic acid; (dichloromethylene)diphosphonic acid; dichloromethanediphosphonic acid; Cl2MDP; DMDP.
CH4Cl2O6P2; mol wt 244.89.
C 4.90%, H 1.65%, Cl 28.95%, O 39.20%, P 25.30%.

Description and references

Bisphosponate antiresorptive agent. Prepn and use as detergent additive: BE 672205 (1966 to Procter and Gamble), C.A. 67, 4040u (1967). Prepn: O. T. Quimby et al., J. Org. Chem. 32, 4111 (1967). Effect on hydroxyapatite durapatite, q.v., crystal aggregation: N. M. Hansen et al., Biochim. Biophys. Acta 451, 549 (1976); S. Bisaz et al., ibid. 560. HPLC determn in urine: V. Virtanen, L. H. J. Lajunen, J. Chromatogr. 617, 291 (1993). Symposium on therapeutic efficacy in neoplastic bone disease: Bone 8, Suppl. 1, S1-S86 (1987). Review of pharmacology and clinical efficacy in resorptive bone disease: G. L. Plosker, K. L. Goa, Drugs 47, 945-982 (1994). Clinical reduction of new metastases in breast cancer: I. J. Diel et al., N. Engl. J. Med. 339, 357 (1998).

Chemical structure

Properties

mp 249-251°.

Derivative

Disodium salt.

Nomenclature

CAS number: 22560-50-5; 88416-50-6 (tetrahydrate)
Clodronate disodium; Bonefos (Schering AG); Clasteon (Abiogen); Clastoban (RPR); Difosfonal (SPA); Loron (Roche); Lytos (Boehringer, Mann.); Mebonat (Boehringer, Mann.); Ossiten (Boehringer, Mann.); Ostac (Boehringer, Mann.).
CH2Cl2Na2O6P2; mol wt 288.86.
C 4.16%, H 0.70%, Cl 24.55%, Na 15.92%, O 33.23%, P 21.45%.

Properties

Occurs as the tetrahydrate.

Therapeutic Category

Bone resorption inhibitor.

Keywords

Antiosteoporotic; Bone Resorption Inhibitor