2377. Clofibrate
Nomenclature
CAS number: 637-07-0
2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester; ethyl 2-(p-chlorophenoxy)-2-methylpropionate; ethyl p-chlorophenoxyisobutyrate; Amotril; Anparton (Sanwa); Apolan (Stockli); Artevil; Ateculon (Nippon Chemiphar); Ateriosan; Atheropront (Mack, Illert.); Atromidin; Atromid-S (Ayerst); Bioscleran (Pfleger); Claripex (Usafarma); Clobren-SF (Morishita); Clofinit (Gentili); CPIB; Hyclorate (Funai); Liprinal (BMS); Neo-Atromid; Normet (Gedeon Richter); Normolipol (Delagrange); Recolip (Benzon); Regelan (Zeneca); Serotinex; Sklerolip (Mepha); Skleromexe (L. Merckle); Sklero-Tablinen (Sanorania); Xyduril (Dorsch). C12H15ClO3; mol wt 242.70.
C 59.39%, H 6.23%, Cl 14.61%, O 19.78%.
Description and references
Prepn: W. G. M. Jones et al., GB 860303; eidem, US 3262850 (1961, 1966 both to I.C.I.). Clinical trials in the primary prevention of ischaemic heart disease: Br. Heart J. 40, 1069 (1978); Lancet 2, 379 (1980). Toxicity data: G. Metz et al., Arzneim.-Forsch. 27, 1173 (1977). Review of pharmacology: M. Chevais, Therapie 35, 5-22 (1980); of metabolism: M. N. Cayen, Rev. Drug Metab. Drug Interact. 3, 77-103 (1980); of toxicity studies: IARC Monographs 24, 39-58 (1980). Comprehensive description: M. M. A. Hassan, A. A. Elazzouny, Anal. Profiles Drug Subs. 11, 197-224 (1982).
Properties
Oil, bp20 148-150°. Practically insol in water. Misc with ethanol, acetone, chloroform, ether. LD50 in mice, rats (g/kg): 1.28, 1.65 orally (Metz).Derivative
Mixture with androsterone.Nomenclature
CAS number: 8075-95-4
Atromid (Ayerst). Therapeutic Category
Antilipemic.
Keywords
Antilipemic; Fibrates