2378. Clofibric Acid
Nomenclature
CAS number: 882-09-7
2-(4-Chlorophenoxy)-2-methylpropanoic acid; 2-(p-chlorophenoxy)-2-methylpropionic acid; α-(p-chlorophenoxy)isobutyric acid; chlorophibrinic acid; Arteriohom (Weisskopf); Regulipid (Heilit). C10H11ClO3; mol wt 214.65.
C 55.95%, H 5.17%, Cl 16.52%, O 22.36%.
Description and references
Prepn: Galimberti, Defranceschi, Gazz. Chim. Ital. 77, 431 (1947); Gilman, Wilder, J. Am. Chem. Soc. 77, 6644 (1955); Jones et al., GB 860303 (1961 to I.C.I.). Prepn and resolution of isomers: Witiak et al., J. Med. Chem. 11, 1086 (1968). Activity thought to be due to its displacement of thyroxin and its inhibition of cholesterol biosynthesis. See Chang et al., Biochem. Pharmacol. 16, 2053 (1967); Walsh et al., Arch. Biochem. Biophys. 130, 7 (1969); Witiak et al., J. Med. Chem. 14, 754 (1971). Metabolism: Almirante et al., Boll. Chim. Farm. 108, 292 (1969).
Properties
Crystals from water or methanol, mp 118-119°.Derivative
Basic aluminum salt.Nomenclature
CAS number: 24818-79-9
Alufibrate; Atherolip; Atherolipin (Schwarz). C20H21AlCl2O7; mol wt 471.26.
C 50.97%, H 4.49%, Al 5.73%, Cl 15.05%, O 23.77%.
Derivative
Magnesium salt.Nomenclature
CAS number: 14613-30-0
Magnesium clofibrate; UR-112; Clomag. C20H20Cl2MgO6; mol wt 451.58.
C 53.19%, H 4.46%, Cl 15.70%, Mg 5.38%, O 21.26%.
Properties
White powder, mp 326-328°. Soly in g/100 mg: water 4.5; abs ethanol 0.7; chloroform 0.02.Derivative
Pyridoxine salt.Nomenclature
CAS number: 29952-87-2
Pyridoxine p-chlorophenoxyisobutyrate; Claresan. C10H11ClO3.C8H11NO3; mol wt 383.82.
C 56.33%, H 5.78%, Cl 9.24%, O 25.01%, N 3.65%.
Description and references
Prepn: Sarbach et al., DE 1915497 (1970 to Inst. Rech. Sci.), C.A. 74, 13011g (1971).
Derivative
Ethyl ester see Clofibrate.Derivative
Etofylline ester see Theofibrate.Therapeutic Category
Antilipemic.
Keywords
Antilipemic; Fibrates