2404. Clorexolone

Nomenclature

CAS number: 2127-01-7
6-Chloro-2-cyclohexyl-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonamide; 6-chloro-2-cyclohexyl-3-oxo-5-isoindolinesulfonamide; 5-chloro-2-cyclohexyl-1-oxo-6-sulfamoylisoindoline; 5-chloro-2-cyclohexyl-6-sulfamoylisoindolin-1-one; 5-chloro-2-cyclohexylphthalimidine-6-sulfonamide; M & B 8430; RP-12833; Flonatril (Specia); Nefrolan (M & B).
C14H17ClN2O3S; mol wt 328.81.
C 51.14%, H 5.21%, Cl 10.78%, N 8.52%, O 14.60%, S 9.75%.

Description and references

Prepn: BE 620654; G. E. Lee, W. R. Wragg, US 3183243 (1963, 1965 both to May & Baker).

Chemical structure

Properties

Prisms, mp 266-268°. Soly in water at 25°: 16 mg/l.

Therapeutic Category

Diuretic.

Keywords

Diuretic; Sulfonamide Derivatives