2405. Cloricromen

Nomenclature

CAS number: 68206-94-0
[[8-Chloro-3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]acetic acid ethyl ester; ethyl [[8-chloro-3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]acetate; 8-monochloro-3-(β-diethylaminoethyl)-4-methyl-7-ethoxycarbonylmethoxycoumarin; 8-chlorocarbochromen; AD6.
C20H26ClNO5; mol wt 395.88.
C 60.68%, H 6.62%, Cl 8.96%, N 3.54%, O 20.21%.

Description and references

Derivative of coumarin, q.v. Prepn: F. della Valle, BE 871315; idem, US 4452811 (1979, 1984 both to Fidia). In vivo studies of activity as coronary vasodilator: F. Aporti et al., Pharmacol. Res. Commun. 10, 469 (1978); as inhibitor of platelet aggregation: M. Prosdocimi et al., Thromb. Res. 39, 399 (1985). Pharmacology in human platelets: R. A. Travagli et al., ibid. 54, 327 (1989). Mechanism of action: S. Porcellati et al., Agents Actions 29, 364 (1990).

Chemical structure

Properties

Crystals from ethyl acetate, mp 147-148°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 74697-28-2
Cromocap (Fidia); Proendotel (Fidia).
C20H26ClNO5.HCl; mol wt 432.34.
C 55.56%, H 6.29%, Cl 16.40%, N 3.24%, O 18.50%.

Properties

mp 219-220°.

Therapeutic Category

Antithrombotic; vasodilator (coronary).

Keywords

Antithrombotic; Vasodilator (Coronary)