2406. Clorindione

Nomenclature

CAS number: 1146-99-2
2-(4-Chlorophenyl)-1H-indene-1,3(2H)-dione; 2-(p-chlorophenyl)-1,3-indandione; 2-(4-chlorophenyl)indan-1,3-dione; chlophenadione; G-25766; MG-2552; Indaliton (Geigy).
C15H9ClO2; mol wt 256.68.
C 70.19%, H 3.53%, Cl 13.81%, O 12.47%.

Description and references

Prepn: Cavallini et al., Farmaco Ed. Sci. 10, 710 (1955); GB 748251 (1956 to Geigy). Pharmacokinetics: Danek, Pogonowska-Wala, Pol. J. Pharmacol. Pharm. 25, 307 (1973), C.A. 79, 111540b (1973). Toxicity study: Fontaine et al., Med. Pharmacol. Exp. 17, 497 (1967).

Chemical structure

Properties

Dark red needles from alcohol, pale yellow needles from dil acetic acid, mp 145-146°. Practically insol in water. Sol in organic solvents except petr ether. LD50 orally in mice: 1220 mg/kg (Fontaine).

Therapeutic Category

Anticoagulant.

Keywords

Anticoagulant