Description and references

Cyclic polypeptide antibiotic produced by Bacillus polymyxa subsp. colistinus. Complex mixture of at least 30 components, primarily colistins A and B. Isoln from Japanese soil: Y. Koyama, JP 52 1546 (1952). Identification of colistins A, B and C: T. Suzuki et al., J. Biochem. (Tokyo) 54, 25 (1963). Structure of colistin A: eidem, ibid. 173, 412. Identity of colistin A with polymyxin E₁: S. Wilkinson, L. A. Lowe, J. Chem. Soc. 1964, 4107. Synthesis of colistin A: R. O. Studer et al., Helv. Chim. Acta 48, 1371 (1965). Prepn of sodium sulfomethyl derivs and toxicity study: M. Barnett et al., Br. J. Pharmacol. Chemother. 23, 552 (1964). Comparative pharmacology of sulfate and methansulfonate salts: A. A. Al-Khayyat, A. L. Aronson, Chemotherapy (Basel) 19, 82 (1973). HPLC determn in medicated animal feeds: B. Cancho-Grande et al., Chromatographia 54, 481 (2001); in human plasma: J. Li et al., J. Chromatogr. B 761, 167 (2001). Review and comparison with polymyxin B, q.v.: J. Horton, G. A. Pankey, Med. Clin. North Am. 66, 135-142 (1982); M. E. Evans et al, Ann. Pharmacother. 33, 960-967 (1999). Review of clinical experience in cystic fibrosis: J. M. Littlewood et al., Respir. Med. 94, 632 (2000); in treatment of multi-resistant bacterial infections: J. Li et al., Int. J. Antimicrob. Agents 25, 11-25 (2005).

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