Description and references

Synthetic polypeptide corresponding to the first 24 amino acids of ACTH, q.v. Identification of activity: R. G. Shepherd et al., J. Am. Chem. Soc. 78, 5067 (1956). Synthesis: H. Kappeler, R. Schwyzer, Helv. Chim. Acta 44, 1136 (1961); eidem, ibid. 46, 1550 (1963); solid-state synthesis: R. Matsueda et al., J. Am. Chem. Soc. 97, 2573 (1975). Assessment of hormone levels for adrenal function in cats: M. E. Peterson et al., Res. Vet. Sci. 37, 331 (1984); in dogs: L. A. Frank et al., Domest. Anim. Endocrinol. 24, 43 (2003). Review as diagnostic aid in assessment of secondary adrenal insufficiency: T. A. M. Abdu, R. N. Clayton, Curr. Opin. Endocrinol. Diabetes 7, 116-121 (2000); in primary or secondary adrenal insufficiency: R. I. Dorin et al., Ann. Intern. Med. 139, 194-204, e205-e206 (2003).

Derivative