2553. Cotinine

Nomenclature

CAS number: 486-56-6
1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone; N-methyl-2-(3-pyridyl)-5-pyrrolidone.
C10H12N2O; mol wt 176.22.
C 68.16%, H 6.86%, N 15.90%, O 9.08%.

Description and references

Nicotine metabolite first described by Pinner, Arch. Pharm. 231, 378 (1893). Isolated from autoxidized nicotine, nicotine treated with hydrogen peroxide, from nicotine irradiated with ultraviolet light: Frankenburg, Vaitekunas, J. Am. Chem. Soc. 79, 149 (1957).

Chemical structure

Properties

Viscous oil, bp6 210-211°. Absorption spectra: Frankenburg, Vaitekunas, loc. cit.

Derivative

Fumarate.

Nomenclature

CAS number: 5695-98-7
Scotine (Unimed).
(C10H12N2O)2.C4H4O4; mol wt 468.50.
C 61.53%, H 6.02%, N 11.96%, O 20.49%.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Pyrrolidones