2592. Croscarmellose Sodium

Nomenclature

CAS number: 74811-65-7
Ac-Di-Sol (FMC).

Description and references

Internally cross-linked form of carboxymethylcellulose sodium (NaCMC), q.v. Prepd by lowering pH of NaCMC in solution, then heating: Technical Literature, FMC Corp. Use as tablet disintegrant: D. Gissinger, A. Stamm, Pharm. Ind. 42, 189 (1980); M. E. Sangalli et al., Boll. Chim. Farm. 128, 242 (1989). Evaluation of drug-excipient interaction: R. G. Hollenbeck et al., J. Pharm. Sci. 72, 325 (1983). Water sorption and thermal behavior: D. Faroongsarng, G. E. Peck, Drug Dev. Ind. Pharm. 20, 779 (1994). Mechanism of action study: R. Thibert, B. C. Hancock, J. Pharm. Sci. 85, 1255 (1996).

Properties

Free flowing, odorless, white powder. Bulk density (g/cc) 0.48. pH 5.0-7.0. Hydrophillic. Insol in water.

Use

Pharmaceutic aid (tablet disintegrant).