2594. Crotamiton

Nomenclature

CAS number: 483-63-6
N-Ethyl-N-(2-methylphenyl)-2-butenamide; N-ethyl-o-crotonotoluidide; crotonyl-N-ethyl-o-toluidine; Crotamitex (Gepepharm); Eurax (Ranbaxy); Euraxil (Novartis); Veteusan (Veterinaria).
C13H17NO; mol wt 203.28.
C 76.81%, H 8.43%, N 6.89%, O 7.87%.

Description and references

Scabicide with antipruritic activity. Prepd by treating crotonic acid o-toluidide with diethyl sulfate: CH 253472; CH 253473; GB 615137 (1949 to Geigy). HPLC is plasma and urine: A. Sioufi et al., J. Chromatogr. 494, 361 (1989) DOI PubMed; in pharmaceutical formulations: S. Izumoto et al., J. Pharm. Biomed. Anal. 15, 1457 (1997) DOI PubMed. Clinical trial in pediatric scabies: D. Konstantinov et al., J. Int. Med. Res. 7, 443 (1979) PubMed.

Chemical structure

Properties

Yellowish oil, bp13 153-155°. Sol in methanol, ethanol.

Therapeutic Category

Ectoparasiticide.

Therapeutic Category (Veterinary)

Scabicide; antipruritic.

Keywords

Ectoparasiticide