2627. Cupric Bisglycinate
Nomenclature
CAS number: 13479-54-4
Bis(glycinato-κN,κO)copper; cupric aminoacetate; glycocoll-copper; Copper Chelazome (Albion). C4H8CuN2O4; mol wt 211.66.
C 22.70%, H 3.81%, Cu 30.02%, N 13.24%, O 30.24%.
Description and references
Prepn: J. Mauthner, W. Suida, Monatsh. Chem. 11, 373 (1890); and characterization: H. Ley, Z. Elektrochem. 10, 954 (1904); and isomerization study: K. Tomita, Bull. Chem. Soc. Jpn. 34, 280 (1961). Thermodynamics of complex formation: K. P. Anderson et al., Inorg. Chem. 5, 2106 (1966). Kinetics of complex formation: A. F. Pearlmutter, J. Stuehr, J. Am. Chem. Soc. 90, 858 (1968). Clinical evaluation in maintenance of bone mineral density: J. Eaton-Evans et al., J. Trace Elem. Exp. Med. 9, 87 (1996).
Derivative
Monohydrate.Properties
Long, deep-blue, rhombic needles. Loses H2O at 123°, chars at 213°, and dec with gas evolution at 228°. Sol in water; slightly sol in alcohol.Derivative
Dihydrate.Properties
Light blue, powdery crystals. Loses one H2O at 103°, remaining H2O at about 140°. Dec with gas evolution at about 225°. Sol in water.Therapeutic Category
Copper supplement.
Therapeutic Category (Veterinary)
Nutritional factor. Given parenterally for copper deficiency in ruminants.Keywords
Replenishers/Supplements; Copper