2712. Cyclobendazole

Nomenclature

CAS number: 31431-43-3
[5-(Cyclopropylcarbonyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester; ciclobendazole; CC-2481; R-17147; Haptocil (Cilag-Chemie).
C13H13N3O3; mol wt 259.26.
C 60.22%, H 5.05%, N 16.21%, O 18.51%.

Description and references

Prepn: J. L. Van Gelder et al., DE 2029637; eidem, US 3657267 (1971, 1972 both to Janssen). Synthesis and anthelmintic activity: A. H. M. Raeymaekers et al., Arzneim.-Forsch. 28, 586 (1978). Embryotoxic and antimitotic properties: P. Delatour, Y. Richard, Therapie 31, 505 (1976). Pharmacokinetics: R. R. Brodie et al., Arzneim.-Forsch. 27, 593 (1977). Biotransformation: B. C. Mayo et al., Drug Metab. Dispos. 6, 518 (1978). Clinical evaluation: A. Degrémont, E. Stahel, Schweiz. Med. Wochenschr. 108, 1430 (1978).

Chemical structure

Properties

Crystals from acetic acid, mp 250.5°.

Therapeutic Category

Anthelmintic (Nematodes).

Keywords

Anthelmintic (Nematodes)