2745. Cyclopenthiazide

Nomenclature

CAS number: 742-20-1
6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-chloro-3-cyclopentylmethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3-cyclopentylmethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; cyclomethiazide; tsiklometiazid; Su-8341; Navidrex (Goldshield); Salimid.
C13H18ClN3O4S2; mol wt 379.88.
C 41.10%, H 4.78%, Cl 9.33%, N 11.06%, O 16.85%, S 16.88%.

Description and references

Prepn: Whitehead et al., J. Org. Chem. 26, 2814 (1961); BE 587225 (1960 to Ciba). Pharmacology: W. E. Barrett et al., Arch. Int. Pharmacodyn. 131, 325 (1961).

Chemical structure

Properties

Crystals from dil alc, mp 230°. LD50 in rats, mice (mg/kg): 141.8 ±24, 232.4 ±25 i.v. (Barrett).

Therapeutic Category

Antihypertensive.

Keywords

Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs