2746. Cyclopentolate
Nomenclature
CAS number: 512-15-2
α-(1-Hydroxycyclopentyl)benzeneacetic acid 2-(dimethylamino)ethyl
ester; 1-hydroxy-α-phenylcyclopentaneacetic acid 2-(dimethylamino)ethyl
ester; 2-dimethylaminoethyl 1-hydroxy-α-phenylcyclopentaneacetate; β-dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate; 2-phenyl-2-(1-hydroxycyclopentyl)ethanoic acid β-(dimethylamino)ethyl
ester. C17H25NO3; mol wt 291.39.
C 70.07%, H 8.65%, N 4.81%, O 16.47%.
Description and references
Ophthalmic anticholinergic. Prepn: Treves, US 2554511 (1951 to Schieffelin).
Derivative
Hydrochloride.Nomenclature
CAS number: 5870-29-1
Ak-Pentolate (Akorn); Alnide (Cusi); Mydplegic (Cooper); Cyclogyl (Alcon); Mydrilate (Boehringer, Ing.); Zyklolat (Mann). C17H25NO3.HCl; mol wt 327.85.
C 62.28%, H 7.99%, N 4.27%, O 14.64%, Cl 10.81%.
Properties
Crystals from ethyl acetate, mp 137-141°. pH of 1% aq soln: 5.0-5.4. Freely sol in water, alcohol. Practically insol in ether.Therapeutic Category
Mydriatic.
Keywords
Mydriatic; Antimuscarinic