2785. Cythioate

Nomenclature

CAS number: 115-93-5
Phosphorothioic acid O-[4-(aminosulfonyl)phenyl] O,O-dimethyl ester; phosphorothioic acid O,O-dimethyl ester O-ester with p-hydroxybenzenesulfonamide; O,O-dimethyl O-p-sulfamoylphenylphosphorothioate; CL-26691; ENT-25640; Proban.
C8H12NO5PS2; mol wt 297.29.
C 32.32%, H 4.07%, N 4.71%, O 26.91%, P 10.42%, S 21.57%.

Description and references

Organophosphate insecticide; cholinesterase inhibitor. Prepn: G. Berkelhammer, US 3005004 and R. I. Hewitt, G. Berkelhammer, US 3179560 (1961, 1965 to Am. Cyanamid). Pharmacodynamics: H. G. Smith, R. L. Goulding, J. Econ. Entomol. 63, 1640 (1970) PubMed. Efficacy as ectoparasiticide: C. P. Doval, I. Gupta, Indian Vet. J. 55, 890 (1978); P. M. Bowen, N. J. Caldwell, Vet. Med. Small Anim. Clin. 77, 79 (1982) PubMed. Toxicity data: E. E. Kenaga, W. E. Allison, Bull. Entomol. Soc. Am. 15, 85 (1969).

Chemical structure

Properties

Crystals, mp 70-71°. nD25 1.5346. LD50 orally in rats: 160 mg/kg (Kenaga, Allison).

Therapeutic Category (Veterinary)

Ectoparasiticide.