2813. Danofloxacin

Nomenclature

CAS number: 112398-08-0
1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-3-quinolinecarboxylic acid.
C19H20FN3O3; mol wt 357.38.
C 63.85%, H 5.64%, F 5.32%, N 11.76%, O 13.43%.

Description and references

Fluorinated quinolone antibacterial. Prepn: M. R. Jefson, P. R. McGuirk, EP 215650; eidem, US 4861779 (1987, 1989 both to Pfizer). See also: F. R. Busch et al., EP 342849 (1989 to Pfizer), C.A. 113, 6177m (1990). Evaluation in treatment of pneumonia in cattle: W. T. R. Grimshaw et al., Dtsch. Tieraerztl. Wochenschr. 97, 529 (1990); C. J. Giles et al., Vet. Rec. 128, 296 (1991). Efficacy in treatment of E. coli diarrhoea in calves: S. J. Sunderland et al., Res. Vet. Sci. 74, 171 (2003).

Chemical structure

Properties

mp 268-272°.

Derivative

Methanesulfonate.

Nomenclature

CAS number: 119478-55-6
CP-76136-27; Advocin (Pfizer).
C19H20FN3O3.CH3SO3H; mol wt 453.48.
C 52.97%, H 5.33%, F 4.19%, N 9.27%, O 21.17%, S 7.07%.

Therapeutic Category (Veterinary)

Antibacterial.