Description and references

Highly potent analog of the posterior pituitary hormone oxytocin, q.v., differing in structure at the 1 position where the free amino group in the half-cystine residue is replaced by hydrogen. Synthesis and biological activity: du Vigneaud et al., J. Biol. Chem. 235, P.C. 64 (1960); Hope et al., ibid. 237, 1563 (1962); Takashima et al., J. Am. Chem. Soc. 90, 1323 (1968). Isoln and purifn: Ferrier et al., J. Biol. Chem. 240, 4264 (1965). Structure-activity correlation: Jarvis, du Vigneaud, Science 143, 545 (1964). Synthesis of d-isomer: G. Flouret, V. du Vigneaud, J. Med. Chem. 14, 556 (1971). Crystal structure analysis: S. P. Wood et al., Science 232, 633 (1986). Pharmacology and comparison with oxytocin: Chan, du Vigneaud, Endocrinology 71, 977 (1962). Review: Adv. Exp. Med. Biol. vol. 2, 53-104 (1968).

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Derivative