6979. Oxytocin

Description and references

The principal uterus-contracting and lactation-stimulating hormone of the posterior pituitary gland. Isoln: Pierce et al., J. Biol. Chem. 199, 929 (1952). Structure and synthesis: Tuppy, Michl, Monatsh. Chem. 84, 1011 (1953); Tuppy, Biochim. Biophys. Acta 11, 449 (1953); du Vigneaud et al., J. Am. Chem. Soc. 75, 4879 (1953); 76, 3115 (1954); Bodanszky, du Vigneaud, ibid. 81, 2504 (1959); Cash et al., J. Med. Pharm. Chem. 5, 413 (1962); Sakakibara et al., Bull. Chem. Soc. Jpn. 38, 120 (1965). Solid phase synthesis: Bayer, Hagenmaier, Tetrahedron Lett. 1968, 2037; Ives, Can. J. Chem. 46, 2318 (1968). Synthesis of d-oxytocin: Flouret, du Vigneaud, J. Am. Chem. Soc. 87, 3775 (1965). Description of commercial process: Velluz et al., US 2938891 and US 3076797 (1960, 1963, both to Roussel-UCLAF). Radioimmunoassay: T. Chard, Clin. Biochem. Anal. 5, 209 (1977). Review: du Vigneaud, Experientia Suppl. II (14th Intl. Congr. Pure and Appl. Chem.), 9-26 (1955); R. Caldeyro-Barcia, H. Heller, Proc. Intl. Symp. on Oxytocin (Montevideo 1959) 443 pp; several authors, Adv. Exp. Med. Biol. 2, 53-104 (1968); C. R. W. Edwards in Hormones in Blood vol. 2, C. H. Gray, V. James, Ed. (Academic Press, New York, 3rd ed., 1979) pp 401-421. Review of role in parturition: A.-R. Fuchs, F. Fuchs, Adv. Exp. Med. 1980, 403-428. Comprehensive description: F. Nachtmann et al., Anal. Profiles Drug Subs. 10, 563-600 (1981). Book: Oxytocin: Cellular and Molecular Approaches in Medicine and Research, R. Ivell, J. A. Russell, Eds. (Plenum Press, New York, 1995) 673 pp.

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