2852. Decimemide

Nomenclature

CAS number: 14817-09-5
4-(Decyloxy)-3,5-dimethoxybenzamide; EGYT-1050; Denegyt.
C19H31NO4; mol wt 337.45.
C 67.63%, H 9.26%, N 4.15%, O 18.97%.

Description and references

Prepn: NL 6605460; E. Kasztreiner et al., US 3432549 (1966, 1969 both to EGYT). Pharmacology: E. Kasztreiner, Magy. Kem. Lapja 27, 370 (1972), C.A. 78, 66697z (1973); I. Kiraly et al., Acta Physiol. Acad. Sci. Hung. 47, 200 (1976). Metabolism study: G. Molnar et al., Acta Pharm. Hung. 48, Suppl., 58 (1978). Toxicity data: E. Usdin, D. H. Efron, Eds., Psychotropic Drugs and Related Compounds (NIH, Washington, D. C., 2nd Ed., 1972) p 377.

Chemical structure

Properties

Cryst from methanol, mp 121-122°. LD50 in mice, rats (mg/kg): 2950, 1650 orally (Udsin, Efron).

Therapeutic Category

Anticonvulsant.

Keywords

Anticonvulsant