2878. Delmadinone Acetate

Nomenclature

CAS number: 13698-49-2
17-(Acetyloxy)-6-chloropregna-1,4,6-triene-3,20-dione; 6-chloro-17-hydroxypregna-1,4,6-triene-3,20-dione acetate; 1,6-bisdehydro-6-chloro-17α-acetoxyprogesterone; Δ1-chlormadinone acetate; RS-1301; Delminal (Rh^one-Mérieux); Estrex (Syntex); Tardastrex (Gruntex); Tarden (Veterinaria); Zenadrex (Veterinaria).
C23H27ClO4; mol wt 402.91.
C 68.56%, H 6.75%, Cl 8.80%, O 15.88%.

Description and references

Prepn: Ringold et al., J. Am. Chem. Soc. 81, 3485 (1959); GB 890315 (1962 to Upjohn), C.A. 57, 5996c (1962); 76, 14813y (1972); Campbell, Babcock, DE 1243682 (1967 to Upjohn), C.A. 67, 100343r (1967). Activity studies: Dorfman, Kincl, Steroids 1, 185 (1963); Weichert et al., Arzneim.-Forsch. 17, 1103 (1967); Gerber et al., J. Small Anim. Pract. 14, 151 (1973).

Chemical structure

Properties

Crystals, mp 168-170°. [α]D -83° (chloroform). uv max (ethanol): 229, 258, 297 nm (log ε 4.00, 4.00, 4.03).

Therapeutic Category

Progestogen.

Therapeutic Category (Veterinary)

Progestogen.

Keywords

Progestogen