2879. Delmopinol

Nomenclature

CAS number: 79874-76-3
3-(4-Propylheptyl)-4-morpholineethanol.
C16H33NO2; mol wt 271.44.
C 70.80%, H 12.25%, N 5.16%, O 11.79%.

Description and references

Surface-active agent that reduces dental plaque formation. Prepn: BE 888052; S. E. H. Hernestam et al., US 4636382 (1981, 1987 both to Ferrosan). Stereoselective HPLC determn in plasma: G. Egginger et al., J. Chromatogr. A 666, 275 (1994). In vitro effect on bacterial cell walls: J. Rundegren et al., Oral Microbiol. Immunol. 10, 102 (1995). Home usage trials of mouthwash: A. J. Elworthy et al., J. Clin. Periodontol. 22, 527 (1995); N. Claydon et al., ibid. 23, 220 (1996).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 98092-92-3
M-1650; Decapinol (Biosurface).
C16H33NO2.HCl; mol wt 307.90.
C 62.41%, H 11.13%, N 4.55%, O 10.39%, Cl 11.51%.

Properties

mp 70-72°. pKa 7.1. Soly in water: >40%.

Therapeutic Category

In treatment of gingivitis.

Keywords

Dental Plaque Inhibitor