2885. Demecarium Bromide

Nomenclature

CAS number: 56-94-0
3,3′-[1,10-Decanediylbis[(methylimino)carbonyloxy]]bis[N,N,N-trimethylbenzenaminium]dibromide; (m-hydroxyphenyl)trimethylammonium bromide, decamethylenebis(methylcarbamate); N,N′-bis[3-trimethylammoniumphenoxycarbonyl]-N,N′-dimethyldecamethylenediamine dibromide; decamethylenebis[m-dimethylaminophenyl N-methylcarbamate] dimethobromide; decamethylenebis[N-methylcarbamic acid m-dimethylaminophenyl ester] bromomethylate; BC-48; Tosmilen (Chemie Linz); Humorsol (Merck & Co.).
C32H52Br2N4O4; mol wt 716.59.
C 53.63%, H 7.31%, Br 22.30%, N 7.82%, O 8.93%.

Description and references

Prepn: Schmid, US 2789981 (1957 to Oesterreichische Stickstoffwerke).

Chemical structure

Properties

White, slightly hygroscopic powder, dec 162-167°. Freely sol in water, alc. Sparingly sol in acetone. Insol in ether. Aq solns are neutral, stable, and may be sterilized by heat.

Therapeutic Category

Cholinergic (ophthalmic).

Keywords

Cholinergic