2884. Demanyl Phosphate

Nomenclature

CAS number: 6909-62-2
Mono[2-(dimethylamino)ethyl]phosphoric acid ester; 2-dimethylaminoethanol dihydrogen phosphate; phosphoryldimethylaminoethanol; phosphoryldimethylcolamine; phosphoryldimethylethanolamine; P-DMEA; Panclar (Lematte et Boinot).
C4H12NO4P; mol wt 169.12.
C 28.41%, H 7.15%, N 8.28%, O 37.84%, P 18.31%.

Description and references

Prepn: Aron-Samuel et al., FR 992802 (1951), C.A. 51, 458e (1957); Cherbuliez, Rabinowitz, Helv. Chim. Acta 41, 1168 (1958); GB 861463; US 3098072 (1961, 1963 to Ciba). The phosphate ester of a possible choline precursor. Has been isolated from a choline-requiring mutant of Neurospora crassa, strain 47904: Wolf, Nyc, J. Biol. Chem. 234, 1068 (1959). Biosynthetic studies: Ansell, Chojnacki, Nature 196, 545 (1962); eidem, Biochem. J. 98, 303 (1966).

Chemical structure

Properties

Crystals, mp 175-176°.

Derivative

Monohydrate.

Properties

mp 78-81°.

Therapeutic Category

Psychotonic.

Keywords

CNS Stimulant