2903. Deoxyepinephrine
Nomenclature
Description and references
Adrenergic and dopamine receptor agonist; active metabolite of ibopamine, q.v. Prepd by heating HCl and 1-keto-6,7-dimethoxy-2-methyltetrahydroisoquinoline obtained from laudanosine or papaverine: Pyman, J. Chem. Soc. 95, 1266, 1610 (1909). Synthesis from veratrole: Kindler, Peschke, Arch. Pharm. 270, 340 (1932); Kindler, Hesse, ibid. 271, 439 (1933). From methylhomoveratrylamine: Buck, J. Am. Chem. Soc. 52, 4119 (1930); Bretschneider, Monatsh. Chem. 76, 335 (1947). Precursor in biosynthesis of epinephrine: W. F. Bridgers, S. Kaufman, J. Biol. Chem. 237, 526 (1962). Cardiovascular pharmacology: I. Martínez-Mir et al., Gen. Pharmacol. 31, 75 (1998). Comparison with 3,4-dihyroxybenzylamine in catecholamine analysis: H. He et al., J. Chromatogr. B 701, 115 (1997).
