Description and references

Inotropic agent with dopaminergic and adrenergic agonist activities; converted to active metabolite, deoxyepinephrine, q.v. Prepn: C. Casagrande, G. Ferrari, DE 2734678; eidem, US 4218470 (1978, 1980 both to Simes). Pharmacology: G. F. Melloni et al., Curr. Ther. Res. 25, 406 (1979); eidem, ibid. 26, 466 (1979). Series of articles on synthesis, pharmacology, clinical efficacy: Arzneim.-Forsch. 36, 285-408 (1986). Review of pharmacodynamics, pharmacokinetics and therapeutic efficacy: J. M. Henwood, P. A. Todd, Drugs 36, 11-31 (1988). Series of articles on clinical use in congestive heart failure: Cardiology 77, Suppl. 5, 1-95 (1990). Clinical efficacy and safety in heart failure: J. R. Hampton et al., Lancet 349, 971 (1997). Clinical evaluation in diagnosis of glaucoma: G. Marchini et al., J. Ocul. Pharmacol. Ther. 17, 215 (2001); in treatment of ocular hypertony: L. C. Ugahary et al., Am. J. Ophthalmol. 141, 571 (2006).

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