2919. Desflurane

Nomenclature

CAS number: 57041-67-5
2-(Difluoromethoxy)-1,1,1,2-tetrafluoroethane; (±)-2-difluoromethyl 1,2,2,2-tetrafluoroethyl ether; I-653; Suprane (Ohmeda).
C3H2F6O; mol wt 168.04.
C 21.44%, H 1.20%, F 67.84%, O 9.52%.

Description and references

Prepd but not claimed: J. P. Russell et al., US 3897502 (1975 to Airco). Prepn and use as anesthetic: R. C. Terrell, US 4762856 (1988 to BOC). Series of articles on pharmacology and physical properties: E. I. Eger II et al., Anesth. Analg. 66, 971-985 (1987); and toxicity studies: eidem, ibid. 1227, 1230. Series of articles on clinical pharmacology and kinetics: Anesthesiology 74, 412-439; 479-498. Review: R. M. Jones, Br. J. Anaesth. 65, 527-536 (1990).

Chemical structure

Properties

Volatile liquid. Slight non-pungent odor. Nonflammable, soda lime stable. bp 23.5°. d 1.44. Vapor pressure (20°): 88.53 kPa. Vapor pressure (22-23°): ≈700mm. Partition coefficient at 37° (blood/gas): 0.424 ±0.024; (saline/gas): 0.225 ±0.002; (oil/gas): 18.7 ±1.1.

Therapeutic Category

Anesthetic (inhalation).

Keywords

Anesthetic (Inhalation)