Nomenclature
CAS number: 120-97-8
4,5-Dichloro-1,3-benzenedisulfonamide; 1,3-disulfamyl-4,5-dichlorobenzene; 4,5-dichloro-1,3-disulfamoylbenzene; Antidrasi; Daranide (Merck & Co.); Oratrol (Alcon).
C
6H
6Cl
2N
2O
4S
2; mol wt 305.16.
C 23.62%, H 1.98%, Cl 23.24%, N 9.18%, O 20.97%, S 21.02%.
Description and references
Prepn: Schultz, US 2835702 (1958 to Merck & Co.).
Properties
Needles from DMSO + water, mp 239-241° (patent, mp 228.5-229°). Practically insol in water. Sol in alkaline solns.Therapeutic Category
Carbonic anhydrase inhibitor.
Keywords
Antiglaucoma; Carbonic Anhydrase Inhibitor