3096. Dicyclohexylcarbodiimide

Nomenclature

CAS number: 538-75-0
N,N′-Methanetetraylbiscyclohexanamine; carbodicyclohexylimide; DCC; DCCI.
C13H22N2; mol wt 206.33.
C 75.67%, H 10.75%, N 13.58%.

Description and references

Coupling agent in peptide synthesis: Sheehan, Hess, J. Am. Chem. Soc. 77, 1067 (1955); Khorana, Chem. Ind. (London) 1955, 1087. Prepn: Schmidt et al., Ber. 71, 1933 (1938); Schmidt, Schnegg, US 2656383 (1953 to Bayer); Stevens et al., J. Org. Chem. 32, 2895 (1967); Bestmann et al., Ann. 718, 24 (1968).

Chemical structure

Properties

Cryst mass, mp 35-36°. bp11 154-156°; bp0.5 98-100°.

Caution

Contact allergen.

Use

In the synthesis of peptides.