3097. Dicyclomine

Nomenclature

CAS number: 77-19-0
[1,1′-Bicyclohexyl]-1-carboxylic acid 2-(diethylamino)ethyl ester; β-diethylaminoethyl 1-cyclohexylcyclohexanecarboxylate; bis(cyclohexyl)carboxylic acid diethylaminoethyl ester; dicycloverin.
C19H35NO2; mol wt 309.49.
C 73.74%, H 11.40%, N 4.53%, O 10.34%.

Description and references

Anticholinergic; binds to muscarinic M1 receptors. Prepn: C. H. Tilford et al., J. Am. Chem. Soc. 69, 2903 (1947); M. G. Van Campen, C. H. Tilford, US 2474796 (1949 to Merrell). Receptor binding study: H. Kilbinger, A. Stein, Br. J. Pharmacol. 94, 1270 (1988). Capillary GC determn in plasma: B. J. Walker et al., J. Chromatogr. 416, 150 (1987). Clinical trial in functional abdominal pain: M. G. Grillage et al., Br. J. Clin. Pract. 44, 176 (1990).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 67-92-5
Bentyl (Aventis); Bentylol (Aventis); Merbentyl (Aventis); Wyovin (Wyeth).
C19H35NO2.HCl; mol wt 345.95.
C 65.96%, H 10.49%, N 4.05%, O 9.25%, Cl 10.25%.

Properties

Crystals from butanone, mp 164-166°. Bitter taste. Sol in water; freely sol in alcohol, chloroform; very slightly sol in ether.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic; Antimuscarinic