3127. Diethylpropion

Nomenclature

CAS number: 90-84-6
2-(Diethylamino)-1-phenyl-1-propanone; 2-diethylaminopropiophenone; α-benzoyltriethylamine; amfepramone.
C13H19NO; mol wt 205.30.
C 76.05%, H 9.33%, N 6.82%, O 7.79%.

Description and references

Prepn: Hyde et al., J. Am. Chem. Soc. 50, 2287 (1928); Schutte, US 3001910 (1961 to Temmler-Werke). Pharmacology: Cahen et al., Therapie 17, 373-412 (1962). Clinical trial in obesity: R. Abramson et al., J. Clin. Psychiatry 41, 234 (1980).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 134-80-5
Anorex (Crinex); Dobesin (Abigo); Moderatan (Theranol); Prefamone (Dexo); Regenon (Temmler); Tenuate (Aventis); Tepanil (3M Pharma).
C13H19NO.HCl; mol wt 241.76.
C 64.58%, H 8.34%, N 5.79%, O 6.62%, Cl 14.66%.

Properties

Crystals, dec 168°.

Note

This is a controlled substance (stimulant): 21 CFR, 1308.14.

Therapeutic Category

Anorexic.

Keywords

Anorexic; CNS Stimulant