3168. Dihexyverine

Nomenclature

CAS number: 561-77-3
[1,1′-Bicyclohexyl]-1-carboxylic acid 2-(1-piperidinyl)ethyl ester; 1-cyclohexylcyclohexanecarboxylic acid β-piperidinoethyl ester; dicyclohexylacetic acid 2-piperidinoethyl ester; dihexiverine.
C20H35NO2; mol wt 321.50.
C 74.72%, H 10.97%, N 4.36%, O 9.95%.

Description and references

Anticholinergic. Prepn: Kopp, Tchoubar, Bull. Soc. Chim. Fr. 1952, 84. Pharmacology: Buchel et al., Arch. Sci. Physiol. 16, 57 (1962); 21, 537 (1967); Guyonneau, Med. Exp. 6, 245 (1962).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 5588-25-0
JL-1078; Metaspas (Leeming); Diverine (Courtois); Olimplex (Vaillant-Defresne); Seclin (Panthox & Burck); Dispas (Ankerfarm); Neospasmina (Biofarmacoterapico); Spasmodex (Crinex); Spasmalex.
C20H35NO2.HCl; mol wt 357.96.
C 67.11%, H 10.14%, N 3.91%, O 8.94%, Cl 9.90%.

Properties

Crystals, mp 175° (copper block). mp 200° (capillary). LD50 i.p. in mice: 212 mg/kg (Buchel).

Therapeutic Category

Antispasmodic.

Keywords

Antimuscarinic; Antispasmodic