3169. Dihydralazine

Nomenclature

CAS number: 484-23-1
2,3-Dihydro-1,4-phthalazinedione dihydrazone; 1,4-dihydrazinophthalazine.
C8H10N6; mol wt 190.21.
C 50.52%, H 5.30%, N 44.18%.

Description and references

Vasodilator. Prepn: J. Druey, US 2484785 (1949 to Ciba); J. Druey, B. H. Ringier, Helv. Chim. Acta 34, 195 (1951); Zerweck, Kunze, US 2786839 (1957 to Cassella Farbw.). Pharmacology: P. A. Van Zwieten, Arzneim.-Forsch. 18, 79 (1968). Mechanism of action: I. W. Reimann et al., Clin. Sci. 61, 319s (1981); eidem, Clin. Exp. Pharmacol. Physiol. 12, 79 (1985). Cerebrovascular effects in rats: L. M. Auer et al., Acta Med. Scand. Suppl. 678, 73 (1983); D. I. Barry et al., Stroke 15, 102 (1984). Hemodynamic responses in man: G. G. Belz, Clin. Pharmacol. Ther. 37, 48 (1985). Clinical studies: A. Salvadeo et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 19, 372 (1981); P. I. Salmela et al., Ann. Clin. Res. 13, 433 (1981). Toxicity data: G. Steiner et al., J. Med. Chem. 24, 59 (1981).

Chemical structure

Properties

Orange needles from water, dec about 180°. LD50 i.p. in rats: 1084 μmol/kg (Steiner).

Derivative

Sulfate.

Nomenclature

CAS number: 7327-87-9
Pressunic (Unipharm).
C8H10N6.H2SO4; mol wt 288.28.
C 33.33%, H 4.20%, N 29.15%, S 11.12%, O 22.20%.

Properties

Needles, dec 233°.

Derivative

Sulfate hemipentahydrate.

Nomenclature

Depressan (OPW); Dihyzin (Henning); Nepresol (Novartis); Népressol (Novartis).

Derivative

Methanesulfonate.

Nomenclature

Dihydralazine mesylate; Nepresol Inject (Novartis).
C8H10N6.CH3SO3H; mol wt 286.31.
C 37.75%, H 4.93%, N 29.35%, S 11.20%, O 16.76%.

Therapeutic Category

Antihypertensive.

Keywords

Antihypertensive; Hydrazines/Phthalazines