3197. Diisopropylamine Dichloroacetate

Nomenclature

CAS number: 660-27-5
Dichloroacetic acid compd with N-(1-methylethyl)-2-propanamine (1:1); dichloroacetic acid diisopropylammonium salt; diisopropylammonium dichloroacetate; diisopropylamine dichloroethanoate; DADA; DIPA-DCA; DIEDI; IS-401; Disotat (Isis); Kalodil (Fidia); Oxypangam (Sanorania).
C8H17Cl2NO2; mol wt 230.13.
C 41.75%, H 7.45%, Cl 30.81%, N 6.09%, O 13.90%.

Description and references

Prepn: GB 862248 (1961 to Italseber). Pharmacology: V. A. E. Kraushaar et al., Arzneim.-Forsch. 13, 109 (1963). Ames mutagenicity test: M. D. Gelernt, V. Herbert, Nutr. Cancer 3, 129 (1982). Pharmacokinetics and TLC determn in racehorses: J.-M. Yang et al., Gen. Pharmacol. 19, 683 (1988). Review of pharmacology: P. W. Stacpoole, J. Clin. Pharmacol. J. New Drugs 9, 282-291 (1969).

Chemical structure

Properties

Crystals, mp 119-121°. Soly in water: >50%. LD50 orally in mice: 1700 mg/kg (Kraushaar).

Therapeutic Category

Vasodilator, hypotensive.

Keywords

Vasodilator (Cerebral); Vasodilator (Peripheral)