3200. Dilazep

Nomenclature

CAS number: 35898-87-4
3,4,5-Trimethoxybenzoic acid (tetrahydro-1H-1,4-diazepine-1,4(5H)-diyl)di-3,1-propanediyl ester; 3,4,5-trimethoxybenzoic acid diester with tetrahydro-1H-1,4-diazepine-1,4(5H)-dipropanol; 1,4-bis[3-(3,4,5-trimethoxybenzoyloxy)propyl]perhydro-1,4-diazepine; N,N′-bis[3-(3,4,5-trimethoxybenzoyloxy)propyl]homopiperazine; N,N′-(bis-ω-hydroxypropyl)homopiperazine 3,4,5-trimethoxybenzoate (diester).
C31H44N2O10; mol wt 604.69.
C 61.57%, H 7.33%, N 4.63%, O 26.46%.

Description and references

Prepn: GB 1107470; H. Arnold et al., US 3532685 (1968, 1970 both to Asta-Werke). Series of articles on pharmacology and metabolism: Arzneim.-Forsch. 22, 639-666 (1972). Toxicology: H. H. Abel et al., ibid. 667. Clinical results: Messerich, Med. Welt 1972, 563.

Chemical structure

Derivative

Dihydrochloride.

Nomenclature

CAS number: 20153-98-4
Asta C 4898; Comelian (Kowa); Cormelian (Viatris); Labitan (Labinca).
C31H44N2O10.2HCl; mol wt 677.61.
C 54.95%, H 6.84%, N 4.13%, O 23.61%, Cl 10.46%.

Properties

Crystals from ethanol, mp 194-198° (monohydrate). LD50 in male mice, male rats (mg/kg): 26.6, 19.1 i.v.; 161, 90.1 i.p.; 3740, >2150 orally (Abel).

Therapeutic Category

Vasodilator (coronary).

Keywords

Vasodilator (Coronary)