3201. Diloxanide

Nomenclature

CAS number: 579-38-4
2,2-Dichloro-N-(4-hydroxyphenyl)-N-methylacetamide; 2,2-dichloro-4′-hydroxy-N-methylacetanilide; N-dichloroacet-4-hydroxy-N-methylanilide; 4-hydroxy-N-methyldichloroacetanilide; Entamide (Boots).
C9H9Cl2NO2; mol wt 234.08.
C 46.18%, H 3.88%, Cl 30.29%, N 5.98%, O 13.67%.

Description and references

Prepn: P. Oxley et al., US 2912438 (1959 to Boots Pure Drug). Spectrophotometric determn in 2-component tablet formulation: S. M. Galal et al., J. Pharm. Belg. 46, 315 (1991). Clinical trial of combination with metronidazole, q.v., in amoebiasis and giardiasis: H. Qureshi et al., J. Int. Med. Res. 25, 167 (1997). Review of clinical experience: J. B. McAuley et al., Clin. Infect. Dis. 15, 464-468 (1992).

Chemical structure

Properties

Crystals from ethyl acetate, mp 175°.

Derivative

Furoate.

Nomenclature

CAS number: 3736-81-0
Diloxanide 2-furoic acid ester; Furamide (Knoll).

Therapeutic Category

Antiamebic.

Keywords

Antiamebic