3204. Dimefline

Nomenclature

CAS number: 1165-48-6
8-[(Dimethylamino)methyl]-7-methoxy-3-methyl-2-phenyl-4H-1-benzopyran-4-one; 8-[(dimethylamino)methyl]-7-methoxy-3-methylflavone; 8-dimethylaminomethyl-7-methoxy-3-methyl-2-phenylchromone.
C20H21NO3; mol wt 323.39.
C 74.28%, H 6.55%, N 4.33%, O 14.84%.

Description and references

Prepn: Da Re et al., Arzneim.-Forsch. 10, 800 (1960); GB 882537; P. Da Re, US 3147258 (1961, 1964 both to Recordati). Pharmacology: Setnikar et al., J. Pharmacol. Exp. Ther. 128, 176 (1960); eidem, J. Med. Pharm. Chem. 3, 471 (1961).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 2740-04-7
Rec-7-0267; Remeflin (Recordati).
C20H21NO3.HCl; mol wt 359.85.
C 66.75%, H 6.16%, N 3.89%, O 13.34%, Cl 9.85%.

Properties

Crystals from alcohol + ether, dec 213-214°.

Therapeutic Category

Respiratory stimulant.

Keywords

Respiratory Stimulant