3205. Dimefox

Nomenclature

CAS number: 115-26-4
Tetramethylphosphorodiamidic fluoride; tetramethyldiamidophosphoric fluoride; bis(dimethylamido)phosphoryl fluoride; fluophosphoric acid di(dimethylamide); bisdimethylaminofluorophosphine oxide; bis(dimethylamido)fluorophosphate; Pestox XIV.
C4H12FN2OP; mol wt 154.12.
C 31.17%, H 7.85%, F 12.33%, N 18.18%, O 10.38%, P 20.10%.

Description and references

Prepd by fluorination of bis(dimethylamido)phosphoryl chloride: Schrader, Angew. Chem. Suppl. 62, 18 (1951); BIOS Final Report No. 714 (1947); Holmsted, Acta Physiol. Scand. Suppl. 90, 33 (1951); Heap, Saunders, J. Chem. Soc. 1948, 1313; GB 692446 (1953); McCombie et al., US 2489917 (1949). Toxicity data: A. J. Okinaka et al., J. Pharmacol. Exp. Ther. 112, 231 (1954). Review: Kilby, Chem. Ind. (London) 1953, 856.

Chemical structure

Properties

Liquid. Fishy odor. d420 1.1151. bp4.0 67°; bp15 86°. nD20 1.4267. Freely sol in water, ether, benzene. Aq solns are stable. LD50 in rats (mg/kg): 5.0 i.p.; 7.5 orally (Okinaka).

Caution

A highly toxic cholinesterase inhibitor. Symptoms similar to parathion, q.v.: Clinical Toxicology of Commercial Products, R. E. Gosselin et al., Eds. (Williams & Wilkins, Baltimore, 5th ed., 1984) Section II, p 299.

Use

Insecticide; acaricide.