3264. Dimetofrine

Nomenclature

CAS number: 22950-29-4
4-Hydroxy-3,5-dimethoxy-α-[(methylamino)methyl]benzenemethanol; 1-(3,5-dimethoxy-4-hydroxyphenyl)-2-(methylamino)ethanol; dimethophrine; dimetrophine.
C11H17NO4; mol wt 227.26.
C 58.14%, H 7.54%, N 6.16%, O 28.16%.

Description and references

Selective α1-adrenergic receptor agonist. Prepn: GB 1145637; M. Giani et al., US 3646144 (1969, 1972 both to Zambeletti). Pharmacology: Scrollini et al., Atti Accad. Med. Lomb. 25, 193, 203 (1970), C.A. 76, 54270a, 54425e (1972). Pharmacokinetics and metabolism: P. Boselli et al., Arzneim.-Forsch. 26, 2038 (1976); M. S. Benedetti et al., ibid. 27, 158 (1977). TLC determn: G. Musumarra et al., J. Chromatogr. 350, 151 (1985). Double blind clinical evaluations: V. Baldrighi et al., Curr. Med. Res. Opin. 9, 78 (1984); U. Marini et al., ibid. 265.

Chemical structure

Properties

mp 178° (dec). pK 9.71.

Derivative

Hydrochloride.

Nomenclature

CAS number: 22775-12-8
Pressamina (Zambeletti).
C11H17NO4.HCl; mol wt 263.72.
C 50.10%, H 6.88%, N 5.31%, O 24.27%, Cl 13.44%.

Properties

mp 171-173°.

Therapeutic Category

Antihypotensive.

Keywords

α-Adrenergic Agonist; Antihypotensive