3265. Dimetridazole

Nomenclature

CAS number: 551-92-8
1,2-Dimethyl-5-nitro-1H-imidazole; RP-8595; Emtryl (Rh^one-Poulenc); Unizole.
C5H7N3O2; mol wt 141.13.
C 42.55%, H 5.00%, N 29.77%, O 22.67%.

Description and references

Prepn: Bhagwat, Pyman, J. Chem. Soc. 127, 1832 (1925).

Chemical structure

Properties

Needles from water, mp 138-139°. Freely sol in alcohol; sparingly sol in cold water, ether.

Derivative

Hydrochloride.
C5H7N3O2.HCl; mol wt 177.59.
C 33.82%, H 4.54%, N 23.66%, O 18.02%, Cl 19.96%.

Properties

Prisms from dil HCl, mp 195°. Freely sol in water, alcohol; sparingly sol in acetone. Also used as the dihydrogen phosphate, freely sol in water.

Therapeutic Category (Veterinary)

Antiprotozoal (Histomonas).