3424. Dopexamine

Nomenclature

CAS number: 86197-47-9
4-[2-[[6-[(2-Phenylethyl)amino]hexyl]amino]ethyl]-1,2-benzenediol; 4-[2-[[6-(phenethylamino)hexyl]amino]ethyl]pyrocatechol; FPL-60278.
C22H32N2O2; mol wt 356.50.
C 74.12%, H 9.05%, N 7.86%, O 8.98%.

Description and references

Dopamine receptor and β2-adrenoreceptor agonist. Prepn: J. B. Farmer et al., EP 72061 (1983 to Fisons). Unlike dopamine, dopexamine has little or no activity at the α- and β1-adrenoceptors: R. A. Brown et al., Br. J. Pharmacol. 85, 599 (1985). Cardiovascular activity in dogs: eidem, ibid. 609. Hemodynamic effects in chronic congestive heart failure: J. R. Dawson et al., Br. Heart J. 54, 313 (1985); G. Svensson et al., Eur. Heart J. 7, 697 (1986). Human renovascular effects: F. Magrini et al., Eur. J. Clin. Pharmacol. 32, 1 (1987). Symposium on pharmacology and clinical efficacy: Am. J. Cardiol. 62, Suppl., 1C-88C (1988).

Chemical structure

Derivative

Dihydrochloride.

Nomenclature

CAS number: 86484-91-5
Dopexamine hydrochloride; FPL-60278AR; Dopacard (Medeus).
C22H32N2O2.2HCl; mol wt 429.42.
C 61.53%, H 7.98%, N 6.52%, O 7.45%, Cl 16.51%.

Derivative

Dihydrobromide.
C22H32N2O2.2HBr; mol wt 518.33.
C 50.98%, H 6.61%, N 5.40%, O 6.17%, Br 30.83%.

Properties

Crystals from ethanol, mp 227-228°.

Therapeutic Category

Cardiotonic.

Keywords

β-Adrenergic Agonist; Cardiotonic; Dopamine Receptor Agonist