3427. Dosmalfate

Nomenclature

CAS number: 122312-55-4
[μ7-[7-[[6-O-[6-Deoxy-2,3,4-tri-O-(sulfo-κO)-α-l-mannopyranosyl]-2,3,4-tri-O-(sulfo-κO)-β-d-glucopyranosyl]oxy]-5-hydroxy-2-[4-methoxy-3-[(sulfo-κO)oxy]pheny]-4H-1-benzopyran-4-onato(7-)]]tetradeca-μ-hydroxyheneicosahydroxytetradecaaluminum; flavalfate; F-3616; Diotul (FAES).
C28H60Al14O71S7; mol wt 2134.93.
C 15.75%, H 2.83%, Al 17.69%, O 53.21%, S 10.51%.

Description and references

Diosmin, q.v., heptakis (hydrogen sulfate) aluminum complex. Prepn: A. Orjales-Venero, R. Mosquera-Pestana, EP 558435; eidem, US 5296469 (1993, 1994 both to FAES). In vivo protective effect in exptl colitis: I. Villegas et al., Eur. J. Pharmacol. 460, 209 (2003). Series of articles on pharmacology, toxicity and clinical studies as gastroprotectant and antiulcerative: Drugs Today 36, Suppl. A, 25-85 (2000).

Chemical structure

Properties

Yellow solid.

Therapeutic Category

Gastroprotectant.

Keywords

Cytoprotectant (Gastric)