3546. Elgodipine

Nomenclature

CAS number: 119413-55-7
4-(1,3-Benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 2-[[(4-fluorophenyl)methyl]methylamino]ethyl 1-methylethyl ester; 2-[(p-fluorobenzyl)methylamino]ethyl isopropyl (±)- 1,4-dihydro-2,6-dimethyl-4-[2,3-(methylenedioxy)phenyl]-3,5-pyridinedicarboxylate.
C29H33FN2O6; mol wt 524.58.
C 66.40%, H 6.34%, F 3.62%, N 5.34%, O 18.30%.

Description and references

Dihydropyridine calcium channel blocker. Prepn: C. F. Torija, J. A. Galiano Ramos, EP 302980; eidem, US 4952592 (1989, 1990 both to Inst. Invest. Desarr. Quimicobiol.). In vitro and in vivo cardiovascular effects: J. Tamargo et al., Arzneim.-Forsch. 41, 895 (1991). Hemodynamic profile: C. Drieu la Rochelle et al., Br. J. Pharmacol. 111, 49 (1994). Clinical evaluation in coronary artery disease: H. Suryapranata et al., Am. J. Cardiol. 69, 1171 (1992). Clinical evaluation in chronic stable angina: D. U. Acharya et al., Eur. Heart J. 15, 665 (1994).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 121489-04-1
IQB-875.
C29H33FN2O6.HCl; mol wt 561.04.
C 62.08%, H 6.11%, F 3.39%, N 4.99%, O 17.11%, Cl 6.32%.

Properties

Crystals from acetone, mp 194-195°. LD50 i.p. in mice: 30-40 mg/kg (Torija, Galiano Ramos).

Therapeutic Category

Antianginal.

Keywords

Antianginal; Calcium Channel Blocker; Dihydropyridine Derivatives