3580. Enfenamic Acid

Nomenclature

CAS number: 23049-93-6
2-[(2-Phenylethyl)amino]benzoic acid; N-phenethyl anthranilic acid; RH-8; Tromaril.
C15H15NO2; mol wt 241.29.
C 74.67%, H 6.27%, N 5.80%, O 13.26%.

Description and references

Non-steroidal anti-inflammatory drug (NSAID). Prepn: S. R. Hashim et al., IN 103066 and IN 114805 (both 1974 to Council Sci. Ind. Res.). Chemistry and pharmacology: P. Sisoda et al., Proc. Symp. CNS Drugs (Council of Scientific and Industrial Research, New Delhi, 1966) pp 238-248. Antithrombotic activity in rheumatoid arthritis and myocardial infarction: S. R. Manikeri et al., Indian J. Med. Res. 71, 438 (1980). Natriuretic activity: N. Kshirsagar et al., Br. J. Clin. Pharmacol. 9, 530 (1980). Clinical trial in nephrotic syndrome: eidem, Indian J. Med. Res. 70, 801 (1979); as postpartum analgesic: S. Tandon et al., Indian Med. Gaz. 116, 182 (1982).

Chemical structure

Properties

Crystals, mp 116-117°. Insol in water. LD50 in mice (mg/kg): 575 i.p., >2000 orally (Sisoda).

Therapeutic Category

Anti-inflammatory; analgesic.