3581. Enflurane

Nomenclature

CAS number: 13838-16-9
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane; 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether; methylflurether; compd 347; NSC-115944; Alyrane (Baxter); Efrane (Abbott); Ethrane (Baxter).
C3H2ClF5O; mol wt 184.49.
C 19.53%, H 1.09%, Cl 19.22%, F 51.49%, O 8.67%.

Description and references

Prepn by fluorination of the corresp dichloromethyl ether: R. C. Terrell, GB 1138406; idem, US 3469011; US 3527813 (1969, 1969, 1970 all to Air Reduction). Synthesis and anesthetic properties: R. C. Terrell et al., J. Med. Chem. 14, 517 (1971); 15, 604 (1972). Enantiomeric resolution: J. Meinwald et al., Science 251, 560 (1991).

Chemical structure

Properties

Stable, volatile, non-flammable liq. bp 56.5°. nD20 1.3025. d2525 1.5167. Does not degrade in the presence of alkali or light. Miscible with other organic liquids incl. fats and oils.

Caution

Potential symptoms of overexposure are eye irritation; CNS depression, analgesia, anesthesia, seizures, respiratory depression. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 128.

Therapeutic Category

Anesthetic (inhalation).

Keywords

Anesthetic (Inhalation)