3606. Eperisone

Nomenclature

CAS number: 64840-90-0
1-(4-Ethylphenyl)-2-methyl-3-(1-piperidinyl)-1-propanone; 4′-ethyl-2-methyl-3-piperidinopropiophenone.
C17H25NO; mol wt 259.39.
C 78.72%, H 9.71%, N 5.40%, O 6.17%.

Description and references

Spasmolytic agent related structurally to tolperisone, q.v. Prepn: E. Morita et al., DE 2458638; E. Morita, T. Kanai, US 4181803 (1975, 1980 both to Eisai). Pharmacological study: K. Tanaka et al., Nippon Yakurigaku Zasshi 77, 511 (1981), C.A. 95, 35471t (1981). Absorption, distribution, excretion in rats and guinea pigs: T. Fujita et al., Oyo Yakuri 21, 835 (1981), C.A. 96, 28193w (1982). Toxicity study: H. Miyagawa et al., ibid. 939, C.A. 96, 79722a (1982).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 56839-43-1
EMPP; E-646; Mional (Eisai); Myonal (Eisai).
C17H25NO.HCl; mol wt 295.85.
C 69.02%, H 8.86%, N 4.73%, O 5.41%, Cl 11.98%.

Properties

Needles from isopropanol, mp 170-172°. LD50 in male S.D. rats, Wistar rats, mice (mg/kg): 1300, 1850, 1024 orally (Miyagawa).

Therapeutic Category

Muscle relaxant (skeletal).

Keywords

Muscle Relaxant (Skeletal)