9522. Tolperisone

Nomenclature

CAS number: 728-88-1
2-Methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone; 2,4′-dimethyl-3-piperidinopropiophenone; 1-piperidino-2-methyl-3-(p-tolyl)-3-propanone; 2-methyl-3-piperidino-1-p-tolylpropan-1-one; mydetone.
C16H23NO; mol wt 245.36.
C 78.32%, H 9.45%, N 5.71%, O 6.52%.

Description and references

Prepn: Nádor et al., HU 144997 (1956); Yokoyama et al., JP 65 20390 (1965 to Eisai). Pharmacology and toxicity: J. Porszasz et al., Acta Physiol. Acad. Sci. Hung. 18, 149 (1960); eidem, Arzneim.-Forsch. 11, 257 (1961).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 3644-61-9
N-553; Abbsa (Sanko); Atmosgen (Maruko); Arantoick (Ohta); Besnoline (Kotobuki); Isocalm (Kaken); Kineorl (Showa Shinyaku); Menopatol (Chemiphar); Metosomin (Maruishi); Minacalm (Tobishi); Muscalm (Nippon Kayaku); Mydocalm (Labatec); Naismeritin (Hishiyama); Tolisartine (Kowa).
C16H23NO.HCl; mol wt 281.82.
C 68.19%, H 8.58%, N 4.97%, O 5.68%, Cl 12.58%.

Properties

Crystals from methyl ethyl ketone, mp 176-177°. LD50 s.c. in mice: 620 mg/kg (Porszasz, 1961).

Therapeutic Category

Muscle relaxant (skeletal).

Keywords

Muscle Relaxant (Skeletal)